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Nicholas Brendon had lived with several health issues and setbacks in the last few years of his life.
“We are heartbroken to share the passing of our brother and son, Nicholas Brendon.
Here is everything to know about Brendon’s health battles during his final years.
Nicholas Brendon’s Cause of Death: How Did He Die?
Brendon died in his sleep “of natural causes,” his family said in their March2026 statement.

What Health Issues Did Nicholas Brendon Have?
Brendon suffered from multiple health problems, including a congenital heart defect and cauda equina syndrome, which led to Brendon undergoing multiple spinal surgeries in his final years.
Per his family’s March2026 statement, it was “no secret that Nicholas had struggles in the past.” Still, the late Criminal Minds star was “on medications and treatment to manage his diagnosis, and he was optimistic about the future at the time of his passing.”
What Is Cauda Equina Syndrome?
Cauda equina syndrome (CES) happens when there is a “dysfunction of multiple lumbar and sacral nerve roots” of the cauda equina — a collection of nerves at the end of the spinal cord, according to the American Association of Neurological Surgeons.
What Causes Causa Equina Syndrome?
CES can result from a massive herniated disc in the lumbar region, per the American Association of Neurological Surgeons.
What Is Tachycardia?
Tachycardia is a congenital heart defect in which the heart beats abnormally fast, which is also known as arrhythmia.

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