Since her 2021 diagnosis, Applegate has become accustomed to the sensation of an open-front gown. “I’ve been in the hospital upwards of 30 times from throwing up and diarrhea and pain,” she relayed on her podcast in March 2025. “That is unimaginable, OK? They’ve done every test known to man on me, put so much radiation into my body from CT scans to everything else.”
On a positive note, she mentioned that she has linked some of her gastro issues to her larger illness. “I have noticed that—and I’m going to be really honest—if I have to poop, I puke,” she detailed. “And when I puke, I get all the pain and then all the things happen.”
Mere months after her hospital confession, Applegate was checking back in. Returning from a family trip to Europe, “I’m like, ‘I wanna be admitted. I’m staying here because I want answers,'” she recounted that August of what she told staff. “‘I want every test that you can possibly think of or ones that you haven’t even thought of, and I want them done.’
Following a middle-of-the-night CT, she learned, “I had kidney infections.”
