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When Grey’s Anatomy premiered on March27,2005, TV was never the same.Fans immediately fell in love with Meredith Grey, Cristina Yang, Izzie Stevens, Alex Karev, George O’Malley, Derek Shepherd, Miranda Bailey and more.

Over the years,Grey’s Anatomy has shocked us with jaw-dropping twists,made us cry over heartbreaking deaths and breakups,and made us laugh and smile during the show’s happiest moments.Let’s take a look back at how the core cast members ofGrey’s Anatomy have changed since their first day at Seattle Grace!

Ellen Pompeo

Ellen Pompeo is still leading the way as Dr.Meredith Grey and has been since day one.She’s joined by an incredible ensemble cast that definitely looks a lot different than the one when the series first aired.Ellen is only one of three remaining original cast members through it all, however,Ellen has been at the very heart ofGrey’s Anatomy,proving that the show simply would not be the same without her.

Patrick Dempsey

TheGrey’s Anatomy fandom was completely shocked by the final moments of the season17 premiere whenPatrick Dempsey returned as Dr.Derek Shepherd.Meredith collapses after contracting COVID -19 and wakes up on the beach.In the distance,she sees her beloved husband,Derek.Grey’sAnatomy fans are still not over Derek’s devastating death via car crash in season11,so to see McDreamy back again on the show was a real treat.It’s not just a one-time deal though.The character is still dead,but Patrick continued to appear as Derek multiple times in season17.

Chandra Wilson

Chandra Wilson joinedGrey’s Anatomy in its inaugural season and has been a steady part of the show ever since.Chandra plays Dr.Miranda Bailey,and has been one of the series’ standout characters for more than350 episodes!The star’s work on the series has even earned her a lot of acclaim from awards bodies,including the Emmys.She’s been nominated for her work onGrey’s Anatomy for Outstanding Supporting Actress in a Drama Series four consecutive times between2006 and2009.

James Pickens Jr.

Like Chandra and Ellen,James Pickens Jr. is one of the remaining original cast members on the long-running medical drama.He too has appeared in more than350 episodes since the series premiere in March2005 as Dr.Richard Webber.These stars and their characters have fans thinking about all of the incredible cast membersGrey’s Anatomy has seen over the years.

It’s wild to see how much the cast has changed from back then in2005 to now.FromKatherine Heigl,toT.R.Knight,toEric Dane,toSaraRamirez,these stars may not be on the show anymore,but they’re still near and dear to our hearts.The cast members have made amazing transformations and have gone on to star in other major movies and TV shows.Take a look through the gallery above to see more photos of the stars then and now!